US Epidemics Quiz: Do You Remember The Outbreaks?

By Danielle Goldsmith
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  • Questions: 10
  • Last Updated: 23 Sep, 2025
  • Attempts: 1
  • liked by 100%
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The history of the U.S. is also a history of epidemics. From smallpox wiping out Native communities, to the 1918 Spanish Flu that killed millions, to more recent challenges like HIV/AIDS, COVID-19, and opioid addiction, epidemics have shaped how Americans view health and safety. Each outbreak brought fear but also progress, leading to new vaccines, better hygiene, and stronger public health systems. Do you know which epidemics changed America forever and how we fought back? This quiz will test your knowledge of U.S. epidemics, both past and present.

The measles outbreak in Disneyland, California, occurred in which year?

  • 2008

  • 2014

  • 2019

  • 2021

The first major polio epidemic in the U.S. occurred in?

  • 1905

  • 1929

  • 1916

  • 1945

The CDC was originally established to combat which disease?

  • Tuberculosis

  • Malaria

  • Smallpox

  • Influenza

Lyme disease, which became widely recognized in the U.S., is primarily transmitted by:

  • Ticks

  • Mosquitoes

  • Fleas

  • Sandflies

SARS-CoV-2 caused which pandemic in the U.S.?

  • H1N1

  • Ebola 

  • COVID-19

  • Zika

Which 1980s epidemic heavily impacted the U.S. LGBTQ+ community?

  • Influenza

  • HIV/AIDS

  • Measles

  • Smallpox

Which U.S. city was the epicenter of the 2014 Ebola scare in America?

  • Dallas

  • New York

  • Atlanta

  • Chicago

The opioid epidemic in the U.S. primarily refers to?

  • Alcohol abuse

  • Coacine use 

  • Tobacco addiction

  • Prescription and illicit opioid misuse

Which epidemic in 2009 caused widespread concern in the U.S.?

  • Ebola

  • H1N1 (Swine Flu)

  • Zika

  • SARS

The 1918 influenza pandemic in the U.S. is commonly known as?

  • Swine flu

  • Spanish flu

  • Asian flu

  • Hong Kong flu

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